Fibroids could be linked to a genetic mutation

Fibroids is one of the most common reasons for a woman to have a hysterectomy and it is believed that over 60% of women will have developed one or more before the age of 45.  In fact there is some evidence to suggest that the majority of women have some sort of fibroid.

Recently researchers in Finland have found that a there was a genetic mutation in the MED12 gene in ten fibroids they compared from a sample study of 18 women.  This particular gene is involved in gene regulation and when they analysed another 207 fibroids they found that 70% of them contained the same genetic mutation.

However, there is very little known about how fibroids form at present and more research is needed to understand this process.  In addition the team noted that all the fibroids came from women at one hospital in Helsinki which means that there could be other, geographic, factors that may be localised impacting on these results as well.



  1. Hi Tina, I am 52 and have been considering having an abdominal hysterectomy for the last couple of years but have been putting if off by trying out the coil. It worked for the first few months, however, it fell out due to sudden heavy clotting. I had a second one put in just in case the first one wasn’t put in properly. Alas, it’s not working and I am having long irregular periods with large clots. My problem is fibroids, several of them which can’t be cut out as they are imbedded into the uterus, one which is the size of an orange. My mother had a prolapse in her 40’s, was given a surgical stitch, which basically held everything up and in place. However, when she was 61 she got uterine cancer, subsequently had a hysterectomy, unfortunately, it was too late,, the cancer had spread and she died aged 62. The doctor had commented that they should have taken everything out when she had the prolapse. I never asked whether she had any fibroids as I was too young at the time to fully understand what was going on. I have now made a decision to have the op, only I am concerned about the recovery and the hormone lose, (if I need to remove my ovaries) and how it will affect my libido/moods etc as it’s pretty low already! Any words of advice on how you have manged this would be helpful.
    Thanks. Anna

  2. My Mum had a hysterectomy due to two tennis ball size fibroids aged 37. I had a hysterectomy due to two grapefruit size fibroids aged 51. Genetic link??

  3. Hi – I have a large fibroid and also have endometriosis, along with a blood clotting disorder that I was told was basically due to a mutant gene. I do wonder whether due to the clotting disorder Factor V Leiden if this is connected to having the endo and the fibroid?

    My sister also has endo and the same clotting factor – mutant gene

    I have a colleague whose sister has endometriosis and she has the blood condition Lupus so it does make you wonder if some form of connection?

Leave a Reply

%d bloggers like this: